Piperidine-GNE-049-N-Boc is a ligand for target protein for PROTAC of dCBP-1 (HY-134582). dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP.

Product information

CAS Number: 1936431-36-5

Molecular Weight: 567.67

Formula: C30H39F2N7O2

Chemical Name: tert-butyl 3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1, 2, 3, 4-tetrahydroquinolin-1-yl]-1-(piperidin-4-yl)-1H, 4H, 5H, 6H, 7H-pyrazolo[4, 3-c]pyridine-5-carboxylate

Smiles: CN1C=C(C=N1)C1=CC2CCCN(C3=NN(C4CCNCC4)C4CCN(CC=43)C(=O)OC(C)(C)C)C=2C=C1C(F)F

InChiKey: NNCJWLPQMSOHBI-UHFFFAOYSA-N

InChi: InChI=1S/C30H39F2N7O2/c1-30(2,3)41-29(40)37-13-9-25-24(18-37)28(35-39(25)21-7-10-33-11-8-21)38-12-5-6-19-14-22(20-16-34-36(4)17-20)23(27(31)32)15-26(19)38/h14-17,21,27,33H,5-13,18H2,1-4H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Piperidine-GNE-049-N-Boc (S17) can be used for synthesizing dCBP-1.

References:

1. Vannam R, et, al. Targeted degradation of the enhancer lysine acetyltransferases CBP and p300. Cell Chem Biol. 2020 Dec 31;S2451-9456(20)30513-4.

Products are for research use only. Not for human use.