Zymax is formulated to enhance digestion, support nutrient uptake & intestinal health.

Zymax contains three fungal proteolytic enzyme systems [including a protease with DPPIV activity, a protease with PEP activity, an aspartic protease (pepsin type)], a cysteine protease (bromelain), amylase, lipase & lactase (tilactase).
It is well known that proline rich dietary proteins such as casein in bovine milk & gluten in cereals resist proteolytic degradation in the human GIT. As a result proline rich fragments can build up & may lead to undesirable effects in specific groups of individuals.

Short chain proline rich bio-active called exorphins such as casomorphins produced from A1 casein & gluteomorphins from gluten, display potent opioid activities. An accumulation of these exorphins in the ENS & CNS may be a contributing factor with some individuals presenting with fatigue, confusion & mood disorders.

Oral supplementation with proline specific endo-protease & exo-protease can assist in removing exorphins. Two proline specific protease of interest are PEP & DPPIV both identified & assayed from two distinct fungal proteolytic enzyme systems produced by the controlled fermentation of non-genetically modified strains of non pathogenic aspergillus oryzae.

DAIRY PRODUCTS
It is known that upon hydrolysis of A1casein a number of new bioactive peptides also called “food hormones” are released. Opioid peptides called casomorphins have been identified & isolated. Beta-casomorphin (1-7) or BCM-7 with the sequence Tyr-Pro-Phe-Pro-Gly-Pro-Ile is the principle opioid peptide in A1 bovine milk. BCM is rapidly processed by the proline specific protease called DPPIV located next to lactase in the brush border membrane of the small intestines of healthy individuals.

DEGRADATION OF BCM-7 WITH DPPIV
Tyr-Pro, Phe-Pro, Gly-Pro, IleA disturbed dipeptidyl peptide IV (DPPIV) enzyme activity, leading to an incomplete breakdown of proline rich peptides may contribute to the development & severity of some health conditions. Oral supplementation with DPPIV type protease & PEP type protease can assist in processing BCM-7.Gluten derived protease resistant exorphins have also been mentioned in this connections. One molecule of Gluten contains 15 opioid sequences. (Fukudome & Yoshikawa (1991) FEBS Letters 296:107-111)

GLUTEN PRODUCTS
Gluten is a difficult protein to digest, the proline & glutamine rich peptides from wheat, rye & barley are relatively resistant to gastrointestinal digestion. the first 100 amino acids in the wheat gluten contains 35% glutamine & 20% proline.

Recently identified long chain proline & glutamine rich gluten fragments, the product of gastric & pancreatic digestion are thought to further resist the proteolytic action of brush border enzymes of the intestines, including DPPIV.

A proline specific endoprotease (PEP) has however shown some benefit in the inactivation of these proline rich rich peptides, into fragments which can be further broken down by the protease of the intestinal brush border membrane including DPPIV.

DIETARY ENZYME SUPPLEMENT PEP
PEP (EC.3.4.21.26) can cleave large intact proteins & polypeptides & the carboxy-terminal end of proline residues. A protease with PEP activity is currently used in the Zymax formulation.

DIETARY ENZYME SUPPLEMENT DPPIV
A protease with DPPIV activity (EC.3.4.14.5) is currently used in the Zymax formulation.The three fungal proteolytic systems [including a protease with DPPIV activity, a protease with PEP activity, a aspartic protease (pepsin type)], a cysteine protease (bromelain), amylase, lipase & lactase (tilactase) incorporated in Zymax can assist in more efficient digestion.

Benefit:

• Zymax is suitable for vegans and vegetarians and can be taken after food or on an empty stomach
• It is odourless and mixes well with drinks
• This product contains no animal ingredients, no added salt, yeast, gluten, wheat, dairy, preservatives, artificial colours, flavours or additives.